Leaky Bitch – Incontinence in female dogs

This is a great topic for understanding clinical decision-making. Not a headliner like brain tumours, but perfect as a simple example of balancing consideration of costs, convenience, and risk, when choosing the treatment for a common problem which, if not controlled, may demand rehoming or even euthanasia. About 1 in 10 of female dogs develop incontinence, anywhere from months to years after their desexing surgery.

incont

Many diseases can be treated a number of ways: with surgery, or with several drugs that vary in price, effectiveness, and risk of side effect.  Deciding which drug is sometimes difficult for both prescriber and pet owner. If there’s only one drug available, side effects are mild, and the disease is life-threatening, the choice can be easy.

The more options there are, and the more serious the potential side effects, the harder it becomes to decide what’s best.  Cost and ease of administration can also be big issues for pet owners, especially for diseases like incontinence where treatment may be daily, for life. Possible hidden side-effects, when drugs are given in the long-term, also raise justifiable  concerns for many.

Incontinence is a topic that sees continual conversation in vet forums, as colleagues try to reconcile these issues. Weighing the pros and cons of each option can be swayed by the information we receive, and how well we cope with risk.

Cause and symptoms

Loss of oestrogen, once ovaries are removed during desexing, results in decreased pelvic nerve and muscle function and hence loss of urinary control.  About 10% of neutered bitches will suffer incontinence; slightly higher for larger breeds, and lower for smaller breeds.

Symptoms range from bed wetting to more constant dribbling; sometimes persistent, others intermittent. The impact on enjoyment of pet ownership can can vary from none, for outdoor dogs, to profound, for those with severely incontinent dogs, living entirely indoors on carpet.

Early onset incontinence (age 2-8) can often be identified as ‘hormonal’ with confidence. In older dogs, incontinence can be secondary to diseases of thirst, and arriving at the vet clinic with jar of urine, ready for analysis, will get your answer quicker. See Liquid Gold: save time & money with urine.

Treatments

These are commonly used alone, but sometimes in combination for stubborn cases.

  • Oestrogenic compounds (Incurin®, Stibestrol/DES)

Could be considered a type of replacement therapy, giving a hormone lost when ovaries were removed,  and therefore looked-upon as addressing the root cause of the problem. These agents are old-school hormones or analogues that are off-patent, and cheap to manufacture.

They usually require an initial higher dose, with tabletting daily, tapering to several times weekly, and sometimes as infrequently as fortnightly. This can make treatment very cheap and easy. Annual cost for a 20kg dog could be as low as $50.

Any oestrogen has the potential to stimulate growth of certain tumours, most commonly breast, or suppress blood cell production in the bone marrow.  These side effects sound catastrophic, especially when treating a non-life threatening problem, and can easily be used by vets and drug manufacturers to guide pet owners towards more expensive alternatives.

In reality, the doses prescribed for incontinence have not been reported  to cause bone marrow problems.   While there are several other sex hormones used in dogs, which do have well-recognised effects on the development of breast cancer and even diabetes, oestrogens, at anti-incontinence doses, don’t appear to be one of them.

Admittedly,  hormones have many and diverse effects in the body, especially in the long term; far more so than  drugs which act on neuromuscular function, described below.   Without large-scale population studies of bitches on treatment it is impossible to say with mathematical certainly, but there isn’t even anecdotal reports or discussion amongst colleagues, implicating oestrogens in any sinister causal role. Progestigens, like megestrol acetate, are a very different matter, and those looking for hazardous use of hormones in pets should fix their gaze in this direction.

Comparison with the recently identified increase in breast tumours in post-menopausal women receiving HRT oestrogens seems superficially valid, although the hormonal life-story of a woman, with pregnancy, breast-feeding and contraceptive pills, is so much more complex than the ovarectomised bitch.  Interestingly, in women, late puberty coupled with early childbirth significantly reduces breast cancer risk, while in the bitch, a similar reduction in risk can be achieved by desexing before their first heat.

If you’re concerned about breast cancer, focus more on the timing of the spey than theoretic side effects this medication.

Cost: …….. Cheap as
Ease: ………A pill weekly to fortnightly
Efficacy: ….83% response rate
Risk: ……….Very Low

.

  • Alpha-adrenergic agents (Propalin®/PPA, Sudafed®/pseudoephidrine)

These are drugs that act on nerve receptors in the ‘valve’ of the bladder neck, stimulating it to contract and maintain continence. Compared to the hormones described above, they are very short-acting and need to be given 1 to 3 times daily. As soon as treatment stops, incontinence returns.  Syrup formulations can be added to food to make administration easier, but they are most effective when given on a empty stomach.  Side effects are uncommon and, like the drug, short-lived. They may include nervousness, insomnia, tremour: not ideal for the anxious or highly strung.

These drugs were freely available at chemists as nasal decongestants (Sudafed®), and slimming tablets (Slim-rite®), until their use in elicit drug manufacture saw a clamp-down on over-the-counter availability. Now marketed as a prescription vet product, Propalin Syrup®, treating a 20kg dog may cost around $250-500 per year, depending on dose. Hence the  financial incentive for vets and drug manufacturers to overstate the risks of inexpensive hormonal drugs and move patients on to these alpha-adrenergic agents.

Cost: …….. Relatively expensive
Ease: ………Dosing several times daily
Efficacy: ….90% response rate
Risk: ……….Very Low

.

  • Acupuncture and chiropractic

Treatments are available. Sourcing information regarding frequency of treatments and efficacy.

  • Traditional Chinese and herbal remedies

Interestingly, some of these remedies may contain natural chemicals that act on adrenergic receptors or as phyto-oestrogens, and hence behave like the man-made drugs above.

  • Lifestyle

The cheapest, drug-free option for incontinence is lifestyle change, as owners of outdoor dogs may not even notice their pet’s incontinence.  Eviction from the house, or restricting access to tiled areas alone, may make the medical problem a non-issue. Many owners can’t cope with the welfare impact of this option; the forlorn looks, from behind glass door, too much to bear.

  • Surgery

There are surgical treatments rarely recommended for incontinence, poorly responsive to pharmaceuticals.  This should be considered as a separate issue, and involve your primary veterinarian and possibly a surgical specialist, as they are costly, invasive, and outcomes are variable.

Recommendation

  • Unless your mother’s death from breast cancer has left a permanent emotional scar, or you can’t cope with risk’s of 1 in the 10′s of thousands, I’d try the hormonal option first. If your bitch responds well, and only low doses are required, it’s safe, easy and cheap.
  • If you don’t like tampering with hormonal systems unnecessarily, you have a chilled-out or relaxed dog, and not phased by the cost, try the alpha-adrenergic agents.
  • If you like natural remedies, get a referral to practitioners who specialise in acupuncture or traditional Chinese medicine.

WARNING: Other diseases of the urinary tract

It’s important to emphasise this conversation is not relevant to other types of incontinence associated with

  • Congenital malformations of the urinary tract, usually in dogs under 6 months of age;
  • Inflammatory lower urinary tract disease (infections, bladder stones) which usually have associated  painful or frequent urination, and malodorous or bloody urine;
  • Spinal diseases, such as slipped discs, tumours and fractured vertebrae, which can damage the nerves supplying the bladder.
  • Polydipsia (increased thirst). These often need to be investigated and treated differently to ‘hormonal incontinence’, although some of these treatments may be used as adjunct to other specific therapies. See Liquid Gold: save time & money with urine.

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49 Responses to “Leaky Bitch – Incontinence in female dogs”

  1. hazel says:

    I copied and pasted this of your website -

    •Unless your mother’s death from breast cancer has left a permanent emotional scar, or you can’t cope with risk’s of 1 in the 10′s of thousands, I’d try the hormonal option first. If your bitch responds well, and only low doses are required, it’s safe, easy and cheap.

    What on earth has this to do with Dog incontinence?

  2. matt says:

    If you read the full article, it describes the theoretic association between breast cancer and oestrogen therapy. Those personally touched by a particular disease, even if in a human relative, may be understandably reluctant to use medication similar to HRT in another loved companion, albeit canine.

  3. Jayne says:

    My kelpie had low dose hormone treatment for incontinence soon after I got her (she was about 18 months old) and about 12 months later she no longer needed the tablets. She is now 6-7 years old and has never had the problem again.

  4. matt says:

    Thats unusual but a great outcome, Jayne. I havent been aware of such permanent responses, but they could go unnoticed by vets – we are only alerted by dog owners if a drug fails rather than succeeds.

  5. Shanon Buckless says:

    Cool. Thanks for writing this. It is always great to see someone educate the community.

  6. Melissa says:

    My 2yr old Boxer started bed wetting a few months after her desexing (at 6months). We tried Propalin first…. worked well so long as you never missed a dose morning or night or dropped below .55mls per dose. Then we tried Stibesterol higher dose at first then dropping to the recommended 1 tablet per week. As soon as we dropped the dose to 1 tab per week the bed wetting started again.

    I guess the answer is leave her on a higher dose? but what is considered a high dose? at what point do the risks outweigh the benefits? do these drugs put pressure on the organs?

  7. matt says:

    hi melissa, your boxer has a greater incontinent tendency than most. With 20/20 hindsight it may have been better to delay desxing until after a few heats, to allow the natural oestrogen cycles to strengthen pelvic floor/bladder neck tone. Although thers no guarantee this would have prevented the problem. The downside of delaying desexing surgery is the associated increase in breast cancer incidence in later life.

    If twice daily propalin is too much of a drag, and you cant change lifestyle to accomodate some incontinence, oestrogens are your only alternative. Its possible, over time, you may be able to decrease the oestrogen dose to 1mg/ week or even lower. While no exact level of DES dose is described as safe, ending up on 25-50% more than the recommended dose wouldn’t conern me if she was my dog.

    The doses that cause oestrogen dependent cancers in experimental studies were about ranging from 60 to 495 mg given over 1 month. Bone marrow suppression has been described at doses about 2.2 mg/kg per day – that would be about 40 x 1mg DES pills a day for your boxer. In this context 1-2 pills per week is a very small dose indeed.

    hope this helps
    matt

  8. Emily says:

    Hi Matt,
    Thanks for the information. I give my 2 yr old mix 25 mg of Proin per day. She’s been on it about a year or so and it works. I’m worried, however, about the anecdotal data about strokes possibly being caused by Proin. I realize this cannot be proved, but I wondered your opinion. Also, do you know anything about the natural remedies such as parsley or soymilk?
    Thanks!
    -Emily

  9. matt says:

    hey emily,
    youre right, pharmacovigilence in the vet context is poor, and its unlikley we’ll see any statistical proof of rarer adverse events any time soon.

    While PPA doesnt have any direct effect on clot/stroke formation, theres definately a potential for PPA to exasserbate underlaying cardiovascular disease. Stroke could occur secondarily.

    The nastier side of any drug is usually revealed by overdose and to quote from Plumb, the vet drug bible…… Symptoms of overdosage may consist of severe cardiovascular (hypertension to rebound hypotension, bradycardias to tachycardias, and cardiovascular collapse) or CNS effects (stimulation to coma) can be seen.
    It wouldnt be difficult to imagine a thromboembolic event arising from overdose, but not at therapeutic doses

    Unless your 2 year old was born with a heart condition, its unlikely she’ll have any heart froblems for a few years yet, so will probably be ok for now.

    Dunno about parsley, but soy milk is probably a source of phyto-oestrogen, and hence may act like the oestrogens described in the article.

    If your concerned about potential sie effects, I’d recommend you explore other options, including acupuncture or herbs, as you dont have anything to lose…..except your paitence having to clean up urine. I’d be interested to hear if parsley worked!

    cheerio

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  12. Janet says:

    Thank you for the readable and informative info on spayed female incontinence. One of the best I have read. My 8 yr. old dog has had this off and on for 2 years and we lived with it and it was becoming more frequent. Started her on DES 1mg in November 2012 and we are kind of stuck at about every 4 or 5 days – just dribbling after that, nothing major. After reading your info I feel comfortable with this although my goal would be to get to once a week or every 2 weeks. I really do not want to add in propalin – I do not feel comfortable with this. Am I correct? Any comments would be helpful.

  13. admin says:

    hi janet, you’re on the right track, tapering the DES to establish minimum effective dose. I agree that getting the dose even lower would be ideal, but 1mg every 5 days is still unlikely to represent any significant long term harm.

    Dont lose hope that further decreases in dose are unachievable. Some find that after many months of treatment the dose can be pushed lower. Some owner discover a seasonal effect, where lower doses can pushed lower, or even stop, during times of year when dogs drink less, such as winter.

    If there are times when incontinence is less consequential, such as boarding kennels, or visiting friends, where a dog is kept outdoors, then periodic ‘DES holidays’ are also possible.

    thanks for the feedback and good luck.
    matt

  14. Janet says:

    Hi Matt:
    Thanks so much for your helpful reply. I am willing to hang in there for a few more months to see how it evolves as it has only been really 2.5full months on DES at this point. I think my expectations were too high. I was interested when you mentioned there may be a seasonal pattern. Even before I read this I had noticed the incontinence was more frequent in the cold months and in our spring and summer she often went for over a month with no issues. It has been unusually cold where I live in Canada this year and we walk in the cold every day. This may be why we seem to be stuck at every 4-5 days for DES, so I look forward to seeing if this changes as the weather warms (can’t come too soon!!) and I will keep you posted. Love your site and I will be back for sure.
    Cheers, Janet

  15. admin says:

    interestingly, ambient temperatures affect the release of a hormone from the brain. ADH, anti-diuretic hormone, released from the pituitary, decreases urine output. Alcohol, tea, coffee, and cold temperatures decrease the release of this hormone, resulting in higher urine output, and hence a greater tendency to incontinence. So, yes, expect more problems in winter, especially after the morning coffee.

  16. Lyn says:

    My little female dog 6yrs (11.5 kg) desexed at 6mths, has become incontintent since about 4yrs of age, it was so frequently until recently so she has only been on Propalin for about 3 months. She was generally a happy soul, but since then she has become increasingly anxious, panting, not her usual self, she is a sporting dog so she gives us a lot of fun, so don’t feel good about upsetting her good nature, any suggestions?
    Thanks,
    Lyn

  17. admin says:

    have you stopped the propalin? anxiety should abate within days or discontinuation. if she is still incontinent, off the propalin, i’d try one of the hormonal options.

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  20. mike says:

    I have a 10 month old lab that has been having incontinent problems since she was 7 months old. she was fixed at 6 months. I took urine in and they tested for infection and found nothing. So they suggested we put her on 25mg of proin (phenylpropanolamine hydrochloride) twice a day. Is this a good choice?

  21. admin says:

    The choices are described above. each has their pros and cons. Just be aware there is a hormonal option which you could try if your in any way dissatisfied with the Prion treatment.

  22. Jane Holt says:

    Hello, reading all these posts with interest as we have a 13 year old Female Boxer who’s been on Propalin 3 times daily for the last four to five months after we noticed she was leaving little dribble patches behind particularly after laying down. She has since put on some weight, seems very restless and is panting a lot. We thought maybe the panting is because she’s hot, after our lovely summer but now I’m wondering if its a side effect of the treatment. I’m planning to take her to the vets this week to get her heart checked and her urine and bloods ans because I didn’t even know there was a hormone option. We don’t want her golden years spent in distress, for her sake and ours. Fingers crossed we can help calm her down a bit and that nothing serious shows up in her tests.

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  24. rachel says:

    hi,just been reading this website ,thankyou for the information.what i really would like to know is does propalin syrup stop working?My greyhound was spayed at 3 years when we rescued her by 4 years she was leaking,she has been on propalin ever since.We tried incurin and it made zero difference.she is now on max dose of0.6 ml 3 times a day.All of a sudden she is leaking profusely everything is soaked and stinky,washing machine is constantly on.I have found some nappies these last 3 hours before seeping occurs and they cost a fortune.she is the grand old age of 13 now and her muscles are disappearing but she still walks 3 times a day up yo 2 miles has a big appetite,but is drinking lots.hope you can help thankyou also she must have some muscle control as she can still produce when squatting.

  25. admin says:

    hi rachel, i fear your dog may have developed a disease of thirst. the loss of control over the incontinence may be due to a tsunami of urine flowing through her system. You should definitely speak with your vet about this, and ideally bring a few urine samples from random times of day.

    good luck

  26. Christine Rudacille says:

    I have an 8.5 year old rescued Greyhound that is having incontinence problems. We put her on the Proin, 1 tablet a day but she pants excessively every time and will not chew the tablets. I had to break up and put in her food. I would like to try the soy milk as an alternative. Do you think this would be a good thing? She also has a problem with stomach upset. She has been eating the Science Diet id food but we have been switching gradually to Nature’s Select, which is grain free, I believe. She has done pretty well on it with just 1 or 2 episodes of upset. One was after a week on the Proin.
    Any suggestions?

    Chris

  27. Lisa says:

    Like Chris, I have a rescue greyhound at about 7- 8 yrs old (exact age unknown) with very recent incontinence issues (dribbling while laying down). She just started Propolin today (2 doses so far) and just had a major bout of the runs. She has IBS…which the vet knows, can side effects like stomach upset/diarhea ease in time? I was interested in the soy milk information too. Could I use it in combination with propolin?
    Lisa

  28. syl says:

    I have a female doberman who will be 3 at the end of next April. She was spayed and now has urinary incontinence. She was on propalin, but due to cost in Canada it would be restrictive to use for the rest of her life. I picked up saw palmetto, (herbal product) which is supposed to be an alternative. I’m assuming its safe to give her but just wondering what the starting dose should be; she weighs 65 lbs and is otherwise in good health.
    Thanks for any suggestions/comments

  29. Jenn says:

    i have a 7 month old lab cross (spayed at 5 months old). In the past week have noticed that she is having leaks when resting, although it is not very strong smelling or yellow urine – quite clear, and only small amounts. We took her to the vet and she is on her second day of DES treatment – we have been told 4 pills for the first week and then, one once a week, How long does this treatment take to work, if it will work? I ask because just today my dog was laying down and while awake (but resting, laying down with her head resting on her paws) she urinated quite a bit! More than I’ve ever seen before. We are lucky in that we do have a tiled house so it’s fairly easy to clean up after, but still a bummer! If she is doing this while awake, could that be a behavioural thing I could train her out of – should i scold her if i catch her pissing whilst awake? She has always been so house trained up until this – very good about letting us know when she has to go and holding it in over night while she is inside, so it’s a bit strange to just see her go in the other direction! Although i do understand it is not her fault and a hormonal thing due to her ovariectomy.

  30. admin says:

    I am sorry, but not familiar with this product or dose.
    maybe follow manufacturers instructions

  31. nikki says:

    My 13 year old staffy (her birthday today), has recently been dribbling and pooling around the house. After a vet visit and check, he gave her some ppa. It worked a treat after 2 days but then the problem came back before the week was out. We went back after a week, and then he started her on the hormone treatment, but recommended we continued with drops till the hormones kicked in. she has been on the hormone and ppa for 6 days and all looked great, but she flooded the hallway this morning AFTER coming in from wee’s and poo’s in the garden and has been dripping all evening in her room!! We got 10 days pills from the vet, and I’m not sure how long this treatment should take to work. Can you advise me at all? Nik x

  32. tami says:

    Hi I have a 10 month old english mastiff. She started her heat cycle about 3 weeks ago and about the same time she started leaking puddles of urine while at rest. It is like she doesnt even know it is happending. I am taking her to the vets tomorrow, looks like she may have a redundant vulva also but has only started leaking the last few weeks.

  33. Bella says:

    I have a 8 year old labxridgeback (26kg). She has been on propalin for almost five years now and suddenly (in the last month) it doesn’t seem to be working. She is on .7mls in the morning and .8mls at night. Sometimes it seems that the propalin dose actually triggers a leak. My poor girl hates it. She isn’t drinking any more than usual and she is peeing on her walks as usual. Is it possible to just no longer respond to propalin after it being successful for so many years? Any insight would be appreciated. Thanks

  34. admin says:

    Hi janelle, yes, there is a potential mechanism of receptor down-regulation, in response to chronic over stimulation by a drug like propalin. Although we dont commonly see it in practice. I’d speak with your vet about increased dose, or trying the hormonal option.

  35. Linda says:

    Hi,
    I have a English springer and she is leaking so much we have been to vet and Propalin, syrup dose .4 ml 3 times a day we have not seen any improvement as yet, I know it worries her she is always looking so sheepish when it is happening to her, when should we see improvement and what would you say the best drug for this is as i see on your blog some are using alternatives.
    she is a vey active dog Bonnie was spayed after second season at around 18 months old she is now 5 years old and we are seeing this in her for the last five to six months and it is very worrying. I am rushing as on my way to work so hope to see your replay when i get back later today . great blog .
    Linda.

  36. admin says:

    Sorry Linda, you havent mentioned how long youve been using the Propalin. Propalin usually works within days, If no effect in a week, i’d stop.

  37. Dawn says:

    Ripley is a my husband’s 3 yr old dobie. She was spayed at 1 yr old, and was cropped and docked as a baby before we got her at 10 wks. About 2 months ago I started noticing her blankets were wet in the morning and after naps, and sometimes when she is out on the porch she wets herself a small amount- she always jumps up and acts surprised. She does have an underactive thyroid which is not medicated-the cost was prohibitive and her vet said not medicating her would just eventually result in her gaining weight if we weren’t careful. Her vet also tested her for UTI and it was negative, we were told incontinence was ‘normal’ in spayed females, no real suggestions were offered. Is it possible the low thyroid condition could be causing her incontinence? Thanks!

  38. admin says:

    Their statement that incontinence is ‘normal’ just shows you how common this problem can be. I am surprised they did not offer you a solution.

    Hypothyroidism can cause neuromuscular weakness, and hence could theoretically contribute to bladder neck incompetency. However I would not overstate the impact of low thryoid hormone, when compared against an almost complete absence of oestrogen and progestigens after removal of ovaries.

    I’d be amazed if thyroxine supplementation had a major effect on the incontinence. I’d be very confident oestrogen replacement would help. Please let me know if you discover otherwise.

  39. nauka jazdy says:

    Incredible points. Outstanding arguments. Keep up the amazing
    effort.

  40. Christina says:

    I have a five year old Labrador retriever. I took her to the vet yesterday after she had some mild incontinence issues. He prescribed Proin 50mg twice a day for her. I gave her one pill last night after dinner. At 2 AM she vomited all of her dinner. I saw on the bottle that 20% of the dogs in the sample (123 dogs) had vomiting as a side effect. I’ve read several posts about dogs having issues with thus drug. Some dogs even died from strokes and cardiovascular issues. I’m very worried about using this drug to help my dog.
    I read that 1/2 teaspoon of parsley mixed into their kibble could help, any suggestions there?

  41. Cara says:

    Thanks for the info regarding treatment options. Our lab-x girl was spayed at 9mos when we got her from SPCA. Noted occasional dribbling of urine when at rest at approx 2yrs age. Read about various options and because of her age (hence need for long term treatment) we started her on dried cornsilk. This managed the condition well for 1yr but recently it is not as effective – was dribbling when walking and when alert. Started her on DES 4 days ago. It has helped, but still have noticed dribbling 1-2 times. Does this mean that it is NOT going to be effective for the long term? Or is there some “breakthrough” dribbling to be expected?

  42. admin says:

    while many onwners report incontinence resolves within days of starting DES, I would persists for up to 2 weeks, on higher dose, before trying to taper. I have not read any literature correlating timing of onset and long term efficacy.

    If there are problems with efficacy it tends to be inability to taper to acceptably low dose, once it has had effect.

    good luck

  43. Cara says:

    Thank you. So what is considered to be an “acceptably low dose”? We were advised after 5 days of daily dose to reduce/taper to 2xwk dose (essentially every 3 days). After 2 days, dribbling. Is every second day acceptable?

  44. Nancy says:

    Hi. I have a 12 year old German Shorthaired Pointer. She became incontinent a little over a year ago and I was prescribled Proin 25mg. She has been taking the pills for about a year and seemed fine for the first few months taking it. She even used to eat it on her own when I put the tablet in her food. Back in April, she began panting heavily when it wasn’t even hot out and she wasn’t running around at that point either. I took her to the vet to see if we could figure out what was wrong. She was diagnosed with Lyme disease and given a 30 day supply of minocycline. There was no change in her after those 30 days so after a few weeks, I took her back to the vet where they did a Lyme c6 (I think that’s what it’s called) test and said her level was still high so I got another 30 day supply of minocycline. She is more than halfway done with that and there is still no change. She is panting excessively, having accidents (both urine and stool) in the house, and not interested in eating her food (she was a vulture when I put it in her bowl before), although she is still into her treats and hounding me for my food. She has also lost all of her spunk…she is lethargic and just lays around and seems depressed. Can a dog all of a sudden become allergic to Proin? This is just a thought that I had tonight. I am going to skip her morning dose tomorrow to see if I see any change in her. Wish me luck. I’m not ready for her to leave me any time soon.

  45. admin says:

    Yes, patients can develop allergies to medication they have been using without any problems, for some time. However none of the symptoms you describe resemble an allergy. It is also possible the panting and lassitude could be an adverse reaction to medication, and observing her off meds could help answer your question. you may have to stop medication for several days to see a benefit. good luck

  46. Dorothy says:

    Hi. My 3 year old kelpie has been having incontinence since she was spayed. Earlier this year she was diagnosed with discospondylitis. The vet started her on incurin tablets and they worked for about a month but the incontinence seems to have come back. I have been told the discopondylitis needs to be managed – is there anyone with a dog with similar illness who can give me some tips please.

  47. Claire says:

    Hi, we have just adopted a 4 year old EBT mix from a rescue. She has a number of issues including anxiety, aggression and high prey drive which we were having some great success working on with positive, reward based training (I’m a dog behaviourist / trainer). However. we soon noticed she was leaking and our vet diagnosed spay incontinence and started her on propalin. The leaking stopped but the medication sends her into a hyperactive frenzied state, even at lower doses. Next option is incurin, is this likely to cause a similar reaction. If so, is there other medication which can be used to counterbalance the effect as her frenzied states are potentially dangerous. Thanks.

  48. admin says:

    no, incurin is an oestrogen, as described in the article. Usually no behavioural effect.

  49. Claire says:

    Thanks so much for your speedy response. Sounds like it makes sense to swap her over.

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